Chapter 9: Linkage, Crossing Over, and Chromosome Mapping

Concepts

• Genes linked on the same chromosome segregate together
• Crossing over serves as the basis of determining the distance between genes during mapping
• Determining the gene sequence during mapping relies on the analysis of multiple crossovers
• Interference effects the recovery of multiple exchanges
• As the distance between two genes increases, mapping experiments become more inaccurate
• Drosophila genes have been extensively mapped
• Crossing over involves a physical exchange between chromatids
• Recombination occurs between mitotic chromosomes
• Exchanges also occur between sister chromatids
• Linkage analysis and mapping can be performed in haploid organisms
• Somatic cell hybridization is an important technique in creating human chromosome maps
• Did Mendel encounter linkage?